| Santa Barbara | 460,000 | Santa Barbara | California | Los Angeles-San Diego, CA | View → |
| Santa Clara | 2,100,000 | San Jose | California | San Francisco, CA | View → |
| Santa Cruz | 48,000 | Nogales | Arizona | Phoenix-Tuscon, AZ | View → |
| Santa Cruz | 280,000 | Santa Cruz | California | San Francisco, CA | View → |
| Santa Fe | 155,000 | Santa Fe | New Mexico | Albuquerque, NM | View → |
| Santa Rosa | 200,600 | Milton | Florida | Mobile, AL-Panama City, FL | View → |
| Sarasota | 448,300 | Sarasota | Florida | Tampa, FL | View → |
| Saratoga | 235,000 | Saratoga Springs | New York | Albany-Utica-Elmira, NY | View → |
| Sargent | 4,000 | Forman | North Dakota | Fargo, ND | View → |
| Sarpy | 200,000 | Papillion | Nebraska | Omaha, NE-Sioux City, IA | View → |
| Sauk | 65,000 | Baraboo | Wisconsin | Madison-La Crosse, WI | View → |
| Saunders | 22,000 | Wahoo | Nebraska | Omaha, NE-Sioux City, IA | View → |
| Sawyer | 17,000 | Hayward | Wisconsin | Green Bay, WI-Duluth, MN | View → |
| Schenectady | 155,000 | Schenectady | New York | Albany-Utica-Elmira, NY | View → |
| Schleicher | 2,500 | Eldorado | Texas | El Paso-Odessa, TX | View → |
| Schley | 5,200 | Ellaville | Georgia | Macon-Columbus, GA | View → |
| Schoharie | 30,000 | Cobleskill | New York | Albany-Utica-Elmira, NY | View → |
| Schoolcraft | 8,000 | Manistique | Michigan | Marquette, MI | View → |
| Schuyler | 6,800 | Rushville | Illinois | Champaign-Peoria, IL | View → |
| Schuyler | 4,600 | Lancaster | Missouri | Ottumwa, IA | View → |
| Schuyler | 17,500 | Watkins Glen | New York | Scranton, PA-Binghamton, NY | View → |
| Schuylkill | 138,000 | Pottsville | Pennsylvania | Scranton, PA-Binghamton, NY | View → |
| Scioto | 76,000 | Portsmouth | Ohio | Charleston-Bluefield, WV | View → |
| Scotland | 35,000 | Laurinburg | North Carolina | Charleston-Florence, SC | View → |
| Scotland | 4,700 | Memphis | Missouri | Ottumwa, IA | View → |
| Scott | 5,000 | Winchester | Illinois | Champaign-Peoria, IL | View → |
| Scott | 175,000 | Davenport | Iowa | Davenport, IA-Moline, IL | View → |
| Scott | 29,000 | Forest | Mississippi | Jackson, MS | View → |
| Scott | 22,000 | Huntsville | Tennessee | Knoxville-Chattanooga, TN | View → |
| Scott | 60,000 | Georgetown | Kentucky | Lexington-Bowling Green, KY | View → |
| Scott | 24,000 | Scottsburg | Indiana | Louisville, KY-Evansville, IN | View → |
| Scott | 155,000 | Shakopee | Minnesota | Minneapolis-St. Paul, MN | View → |
| Scott | 38,000 | Sikeston | Missouri | Paducah, KY | View → |
| Scott | 21,500 | Gate City | Virginia | Tri-Cities, TN/VA | View → |
| Scott | 10,000 | Waldron | Arkansas | Tulsa, OK-Fort Smith, AR | View → |
| Scott | 5,000 | Scott City | Kansas | Wichita, KS | View → |
| Scotts Bluff | 36,000 | Gering | Nebraska | Denver-Colorado Springs, CO | View → |
| Screven | 14,000 | Sylvania | Georgia | Savannah-Augusta, GA | View → |
| Scurry | 16,000 | Snyder | Texas | Lubbock-Abilene, TX | View → |
| Searcy | 8,000 | Marshall | Arkansas | Little Rock, AR | View → |
| Sebastian | 133,000 | Fort Smith | Arkansas | Tulsa, OK-Fort Smith, AR | View → |
| Sedgwick | 2,500 | Julesburg | Colorado | Denver-Colorado Springs, CO | View → |
| Sedgwick | 530,000 | Wichita | Kansas | Wichita, KS | View → |
| Seminole | 8,000 | Donalsonville | Georgia | Montgomery-Dothan, AL | View → |
| Seminole | 24,250 | Seminole | Oklahoma | Oklahoma City, OK | View → |
| Seminole | 482,000 | Sanford | Florida | Orlando-Gainesville, FL | View → |
| Seneca | 34,000 | Waterloo | New York | Buffalo-Rochester-Syracuse, NY | View → |
| Seneca | 55,000 | Tiffin | Ohio | Detroit, MI-Toledo, OH | View → |
| Sequatchie | 16,000 | Dunlap | Tennessee | Knoxville-Chattanooga, TN | View → |
| Sequoyah | 42,500 | Sallisaw | Oklahoma | Tulsa, OK-Fort Smith, AR | View → |
