| Sandhills Solar Farm | fuel | PowerGrid Corp | $3.20 billion | Richmond, North Carolina | |
| Seaside Fuel Storage Depot | fuel | NexaFuel Corp | $720.00 million | Galveston, Texas | |
| Seattle Technology Integration Lab | tech | ParcelPro Logistics | $1.40 billion | King, Washington | |
| Secure Medical Data Vault (Primary) | sfin | HealthGuard | $5.50 billion | Fulton, Georgia | |
| Secure Medical Data Vault (Secondary Redundant Site) | sfin | HealthGuard | $3.90 billion | Salt Lake, Utah | |
| SecureWay Data Fortress North | tech | SecureWay Insurance | $1.45 billion | Hennepin, Minnesota | |
| SecureWay Data Fortress South | tech | SecureWay Insurance | $1.26 billion | Fulton, Georgia | |
| SecureWay Innovation Lab | tech | SecureWay Insurance | $780.00 million | Santa Clara, California | |
| SecureWay National Headquarters | sfin | SecureWay Insurance | $1.90 billion | Cuyahoga, Ohio | |
| SecureWay Northwest Administrative Plaza | sfin | SecureWay Insurance | $410.00 million | Multnomah, Oregon | |
| SecureWay Training & Compliance Institute | sfin | SecureWay Insurance | $210.00 million | Franklin, Ohio | |
| Sierra Audio Engineering Facility | tech | PixelPulse Studios | $430.00 million | Washoe, Nevada | |
| Sierra Nut & Snack Works | food | Harvest Foods | $1.30 billion | Fresno, California | |
| Sierra Ridge AI Research Park | tech | MercuryMart | $18.50 billion | Santa Clara, California | |
| Silicon Valley Micro-Actuator Lab | tech | RoboTech Innovations | $210.00 million | Santa Clara, California | |
| Silver Desert Streaming Hub | tech | StreamSphere | $3.10 billion | Clark, Nevada | |
| Silver Dunes Desert Resort | emc | Oasis Resorts | $5.60 billion | Maricopa, Arizona | |
| Silver Flats Mine | fuel | Bennett Mining | $1.30 billion | Nye, Nevada | |
| Silver Gorge Safety Training Campus | fuel | NexaFuel Corp | $190.00 million | Emery, Utah | |
| SkyHigh Atlanta Flight Technology Center | tech | SkyHigh Airlines | $143.00 million | Fulton, Georgia | |
| SkyHigh Atlanta Lounge & Experience Network | emc | SkyHigh Airlines | $34.00 million | Fulton, Georgia | |
| SkyHigh Atlanta Maintenance & Fuel Complex | fuel | SkyHigh Airlines | $397.00 million | Fulton, Georgia | |
| SkyHigh Atlanta Passenger Operations Hub | sfin | SkyHigh Airlines | $1.74 billion | Fulton, Georgia | |
| SkyHigh Boston�Springfield Flight Technology Center | tech | SkyHigh Airlines | $251.00 million | Suffolk, Massachusetts | |
| SkyHigh Boston�Springfield Lounge & Experience Network | emc | SkyHigh Airlines | $53.00 million | Suffolk, Massachusetts | |
| SkyHigh Boston�Springfield Maintenance & Fuel Complex | fuel | SkyHigh Airlines | $334.00 million | Suffolk, Massachusetts | |
| SkyHigh Boston�Springfield Passenger Operations Hub | sfin | SkyHigh Airlines | $2.44 billion | Suffolk, Massachusetts | |
| SkyHigh Chicago Flight Technology Center | tech | SkyHigh Airlines | $314.00 million | Cook, Illinois | |
| SkyHigh Chicago Lounge & Experience Network | emc | SkyHigh Airlines | $63.00 million | Cook, Illinois | |
| SkyHigh Chicago Maintenance & Fuel Complex | fuel | SkyHigh Airlines | $635.00 million | Cook, Illinois | |
